Publications

At MIT: Coming Soon!

Prior To MIT:

9. Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer

Echtenkamp FJ, Ishida R, Rivera-Marquez GM, Maisia M, Johnson OT, Shrimp JH, Sinha A, Ralph SJ, Nisbet I, Cherukuri MK, Gestwicki JE, Neckers LM.

PNAS Nexus. 2023, DOI: 10.1093/pnasnexus/pgad115

8. Allosteric inhibition of Hsp70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models

Xu P, Yang, JC, Ning S, Chen B, Nip C, Wei Q, Liu L, Johnson OT, Gao AC, Gestwicki JE, Evans CP, Liu C.

Pharmacological Research. 2023, DOI: 10.1016/j.phrs.2023.106692

7. Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry

Wu T, Yu JC, Suresh A, Gale-Day ZJ, Alteen MG, Woo AS, Millbern Z, Johnson OT, Carroll EC, Partch CL, Fourches D, Vinueza NR, Vocadlo DJ, Gestwicki JE.

BioRxiv. 2023, DOI: 10.1101/2023.01.23.525251

6. Multivalent Protein-Protein Interactions Are Pivotal Regulators of Hsp70 Complex Functions

Johnson OT and Gestwicki JE.

Cell Stress and Chaperones. 2022, DOI: 10.1007/s12192-022-01281-1

5. Analogs of the heat shock protein 70 inhibitor MKT-077 suppress medullary thyroid carcinoma cells

Hong S, Starenki D, Johnson O, Gestwicki JE, Park J-I.

Int. J. Mol. Sci. 2022, DOI: 10.3390/ijms23031063

4. Two distinct classes of co-chaperones compete for the EEVD motif in heat shock protein 70 (Hsp70) to tune its activity

Johnson OT*, Nadel CM*, Carroll EC, Arhar T, Gestwicki JE

J. Biol. Chem. 2022, DOI: 10.1016/j.jbc.2022.101697

3. Chemical Validation of a Druggable Site on Hsp27/HSPB1 using In Silico Solvent Mapping and Biophysical Methods

Makely LN*, Johnson OT*, Ghanakota P, Rauch J, Osborn D, Wu T, Cierpicki T, Carlson HA, Gestwicki JE.

Bioorg. Med. Chem. 2021, DOI: 10.1016/j.bmc.2020.115990

2. A Conditionally Fluorescent Peptide Reporter of Secondary Structure Modulation

Johnson OT, Kaur T, Garner AL

ChemBioChem 2019, DOI: 10.1002/cbic.201800377

1. High-Throughput Chemical Probing of Full-Length Protein-Protein Interactions

Song JM, Menon A, Mitchell DC, Johnson OT, Garner AL

ACS Comb. Sci. 2017, DOI: 10.1021/acscombsci.7b00128

*these authors contributed equally